abstract：:K-ras mutation is the most common oncogenic alteration in various human cancers including colorectal carcinomas. Point mutations have the potential to activate the K-ras gene if they occur in the critical coding sequences. Almost all of these mutations have been localized in codons 12, 13 and 61. We report a case of c...

journal_title：Japanese journal of clinical oncology

authors： Miyakura Y,Sugano K,Fukayama N,Konishi F,Nagai H

更新日期：2002-06-01 00:00:00

abstract：:Australia ranks highly internationally for cancer control, in part because cancer registries provide comprehensive national incidence and mortality and other cancer data annually. This has facilitated short- and long-term planning over the last quarter of a century. For example, male death rates from lung cancer in Au...

journal_title：Japanese journal of clinical oncology

authors： Burton RC

更新日期：2002-03-01 00:00:00

abstract：:Malignant neoplasm has become the leading cause of death in Taiwan since 1982. There has been a decreasing trend for cancers of the stomach and cervix uteri, while an increasing trend has been observed for cancers of the lung, liver, oral cavity, colon and rectum, breast and prostate. International comparison and migr...

journal_title：Japanese journal of clinical oncology

authors： Chen CJ,You SL,Lin LH,Hsu WL,Yang YW

更新日期：2002-03-01 00:00:00

abstract：:Chemoradiation is potentially curative for esophageal cancer in various stages, but local failure is a major problem. The present case was a 49-year-old male diagnosed with advanced esophageal cancer with an esophago-bronchial fistula and lymph node metastasis. Histological diagnosis by biopsy was adenosquamous cell c...

journal_title：Japanese journal of clinical oncology

authors： Morihiro M,Boku N,Ohtsu A,Miyamoto S,Ishikura S

更新日期：2002-02-01 00:00:00

abstract：:Although it has been reported that the risk of second malignancies increases in long-term survivors of small cell lung cancer (SCLC) and late recurrence of SCLC is sometimes experienced, it seems uncommon. We recently experienced a case of redevelopment of SCLC after a long disease-free period. The case was considered...

journal_title：Japanese journal of clinical oncology

authors： Kitamoto Y,Hayakawa K,Mitsuhashi N,Tsuchiya S,Saito R

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a...

journal_title：Japanese journal of clinical oncology

authors： Hotta K,Sekine I,Tamura T,Sawada M,Watanabe H,Kusaba H,Akiyama Y,Inoue A,Shimoyama T,Nokihara H,Ueda Y,Yamamoto N,Kunitoh H,Ohe Y,Kodama T,Saijo N

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:In a tumor, increased deubiquitination of cyclins by a protein gene product gene, PGP9.5, could contribute to the uncontrolled growth of somatic cells that is a hallmark of cancer. We hypothesized that PGP9.5 may be expressed in tumors of patients with non-small cell lung cancer (NSCLC). METHODS:Expression ...

journal_title：Japanese journal of clinical oncology

authors： Sasaki H,Yukiue H,Moriyama S,Kobayashi Y,Nakashima Y,Kaji M,Fukai I,Kiriyama M,Yamakawa Y,Fujii Y

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:We investigated the expression of PyNPase both in cancer cells and in stroma cells to clarify the correlation between PyNPase expression and the prognosis of patients with colorectal cancer. METHODS:Using immunohistochemical staining with an anti-PyNPase antibody, the PyNPase expression in tissues from 114 ...

journal_title：Japanese journal of clinical oncology

authors： Osanai T,Ichikawa W,Takagi Y,Uetake H,Nihei Z,Sugihara K

更新日期：2001-10-01 00:00:00

abstract：:Myxoid liposarcoma can frequently metastasize to extrapulmonary sites. We present two cases of myxoid liposarcoma metastatic to the epidural space. Both patients complained of back pain, but plain radiography revealed no abnormality. MR imaging clearly demonstrated metastatic tumors in the epidural space, but no invol...

journal_title：Japanese journal of clinical oncology

authors： Ogose A,Hotta T,Inoue Y,Sakata S,Takano R,Yamamura S

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To assess the feasibility and outcome of concurrent chemoradiotherapy (CT-RT) with large regional field and high-dose external beam boost irradiation in thoracic esophageal cancer. METHODS:Patients with clinical stage T1 (submucosal)-4N0-1M0 (UICC 1997) squamous cell carcinoma of the thoracic esophagus were ...

journal_title：Japanese journal of clinical oncology

authors： Toita T,Ogawa K,Adachi G,Kakinohana Y,Nishikuramori Y,Iraha S,Utsunomiya T,Murayama S

更新日期：2001-08-01 00:00:00

abstract：:BAT-25 is a DNA marker, intragenic to the c-kit protooncogene, assigned to 4q12, containing a polythymine tract, mostly repeats of 25 poly(T) (T25). The BAT-25 locus is frequently used in the analysis of microsatellite instability (MSI) in cancer tissues. The number of poly(T) repeats at BAT-25 is reported to be quasi...

journal_title：Japanese journal of clinical oncology

authors： Ichikawa A,Sugano K,Fujita S

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:There is at present no consensus on the policy for the treatment of patients with low-grade gliomas (LGGs). METHODS:This report is a retrospective multi-institutional study of 100 patients (ages 16-65 years) with astrocytoma (grade II), oligodendroglioma, anaplastic oligodendroglioma and anaplastic oligoast...

journal_title：Japanese journal of clinical oncology

authors： Sakata K,Hareyama M,Komae T,Shirato H,Watanabe O,Watarai J,Takai K,Yamada S,Tsuchida E,Sakai K

更新日期：2001-06-01 00:00:00

abstract：:A 3-year-old girl with Philadelphia chromosome positive acute lymphoblastic leukemia developed pulmonary aspergillosis during severe neutropenia by re-induction therapy. She was treated by intravenous fluconazole, oral itraconazole with plasma level monitoring and surgical resection of the focus for 3 months after cli...

journal_title：Japanese journal of clinical oncology

authors： Kudoh T,Suzuki N,Hatakeyama N,Mizue N,Hori T,Oda T,Watanabe J,Imamura M,Chiba S

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Usually, total and filtered platinum concentrations in plasma are monitored after cisplatin administration. However, these concentrations represent a mixture of unchanged cisplatin and metabolites. In this work, we studied population pharmacokinetic analysis based on these platinum concentrations. METHODS:T...

journal_title：Japanese journal of clinical oncology

authors： Hanada K,Nishijima K,Ogata H,Atagi S,Kawahara M

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Patients suffering from hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) generally have a poor prognosis. We therefore conducted a prospective pilot trial of combined transcatheter arterial chemoembolization (TACE) and local radiotherapy (RT) for PVTT in unresectable HCC. The aim of the ...

journal_title：Japanese journal of clinical oncology

authors： Yamada K,Soejima T,Sugimoto K,Mayahara H,Izaki K,Sasaki R,Maruta T,Matsumoto S,Hirota S,Sugimura K

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:To determine the maximum tolerated dose and recommended dose of cisplatin and docetaxel administered by three consecutive weekly infusions in both non-elderly (< or =74 years) and elderly (> or =75 years) patients, we conducted two independent phase I studies for nonelderly and elderly patients with non-smal...

journal_title：Japanese journal of clinical oncology

authors： Ohe Y,Niho S,Kakinuma R,Kubota K,Matsumoto T,Ohmatsu H,Goto K,Kunitoh H,Saijo N,Nishiwaki Y

更新日期：2001-03-01 00:00:00

abstract：:Uterine inversion caused by uterine sarcoma is a rare condition with 12 reported cases to date according to a MEDLINE search. We report two cases of this rare condition. A 71- and a 72-year-old woman presented with uterine sarcomas rapidly extruded into the vagina. In both cases, magnetic resonance imaging (MRI) scans...

journal_title：Japanese journal of clinical oncology

authors： Takano K,Ichikawa Y,Tsunoda H,Nishida M

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Cytokeratins (CKs) 19 and 20 have been used as targets for detecting cancer cells. We attempted to detect circulating cancer cells in patients with gastric cancer using a high-sensitivity reverse transcriptase-polymerase chain reaction (RT-PCR) assay for CK transcripts. METHODS:RT-PCR for CK 19 and CK 20 wa...

journal_title：Japanese journal of clinical oncology

authors： Majima T,Ichikura T,Takayama E,Chochi K,Mochizuki H

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:To describe computed tomographic (CT) features of highly enhanced hepatic masses as seen on CT during arterial portography (CTAP) and to survey the varieties of hepatic lesions associated with such findings. METHODS:CTAP files for 400 patients were reviewed, on the basis of which six patients with highly en...

journal_title：Japanese journal of clinical oncology

authors： Onaya H,Itai Y,Satake M,Luo T,Saida Y,Haruno M,Hasebe T,Moriyama N

更新日期：2000-10-01 00:00:00

abstract：:Alendronate, a bisphosphonate compound, lowers serum calcium in patients with cancer-associated hypercalcemia through its inhibitory effect on bone resorption and as a result symptoms associated with hypercalcemia improve. This study was carried out to investigate the effects of alendronate in patients with hypercalce...

journal_title：Japanese journal of clinical oncology

authors： Ohnishi T,Takeda E,Yogita S,Miyake H,Kinoshita T,Terashima Y,Matsumoto T,Tashiro S

更新日期：2000-09-01 00:00:00

abstract：:Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-type lymphoma) is a rare thymic tumor, with only seven previous cases described worldwide to date. We describe the only case to have presented with pulmonary amyloid nodules. A 63-year-old Japanese female was found to have an anterior mediastinal tum...

journal_title：Japanese journal of clinical oncology

authors： Moriyama E,Yokose T,Kodama T,Matsuno Y,Hojo F,Takahashi K,Nagai K,Nishiwaki Y,Ochiai A

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Tumor marker-producing germ cell tumors of the central nervous system are malignant and require radiation and/or chemotherapy. Although serum beta-human chorionic gonadotropin (hCG) has been used to monitor the course of treatment, the levels of beta-hCG in the cerebrospinal fluid (CSF) have not been measure...

journal_title：Japanese journal of clinical oncology

authors： Fujimaki T,Mishima K,Asai A,Tabuchi K,Kobayashi M,Suzuki I,Kirino T

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Vital dye-guided sentinel node biopsy is affordable in most hospitals, but may be of limited accuracy in identifying all sentinel nodes. Leaving sentinel nodes in the axilla may result in a false nodal staging of breast carcinomas. METHODS:From a series of 112 successful sentinel lymph node biopsies with Pa...

journal_title：Japanese journal of clinical oncology

authors： Cserni G,Rajtár M,Boross G

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:This study was performed to review retrospectively the clinical course of chronic rectal bleeding as a complication of external beam radiation therapy for localized prostate cancer and to analyze the relationship between technical parameters of radiation therapy and the complications. METHODS:Seventy-one pa...

journal_title：Japanese journal of clinical oncology

authors： Kitamura K,Shirato H,Suzuki K,Shinohara N,Demura T,Harabayashi T,Nishioka T,Kagei K,Takayama N,Shinno Y,Kawakura K,Koyanagi T,Miyasaka K

更新日期：2000-05-01 00:00:00

abstract：:We report on an inflammatory pseudotumor of the spleen. A 72-year-old woman visited our hospital complaining of nausea. Physical examination and laboratory investigations were unremarkable. Ultrasonography, computed tomography, magnetic resonance imaging and angiography showed a hypovascular splenic mass measuring abo...

journal_title：Japanese journal of clinical oncology

authors： Noguchi H,Kondo H,Kondo M,Shiraiwa M,Monobe Y

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The majority of patients with localized and some cases of locally advanced prostate cancer undergo radical prostatectomy. However, radical prostatectomy cannot always be selected for those patients. In this situation, primary hormone therapy is an alternative treatment option. We have designed a prospective ...

journal_title：Japanese journal of clinical oncology

authors： Akaza H,Homma Y,Okada K,Yokoyama M,Moriyama N,Usami M,Hirao Y,Tsushima T,Ohashi Y,Aso Y

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Although there have been extensive studies to determine risk factors affecting survival after resection for hepatocellular carcinoma (HCC), we still do not know which patients can survive disease free after curative resection. This study was undertaken to determine independent risk factors affecting the leng...

journal_title：Japanese journal of clinical oncology

authors： Takata M,Yamanaka N,Tanaka T,Yamanaka J,Maeda S,Okamoto E,Yasojima H,Uematsu K,Watanabe H,Uragari Y

更新日期：2000-02-01 00:00:00

abstract：:Following a simple cholecystectomy, a 63-year-old woman with gallstones was histologically diagnosed as having minute squamous cell carcinoma of the gallbladder. A laparotomy revealed a small, firm nodule that appeared to be an adenoma, which was palpated in the fundus of the gallbladder. The resected gallbladder cont...

journal_title：Japanese journal of clinical oncology

authors： Roppongi T,Takeyoshi I,Ohwada S,Sato Y,Fujii T,Honma M,Morishita Y

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Duodenal carcinoma is very rare and its culture cell lines have rarely been established. METHODS:Tumor cells separated from a surgically resected primary tumor of duodenal carcinoma were put into culture. The patient was an 81-year-old female and had metastatic lymph nodes. We investigated the biological ch...

journal_title：Japanese journal of clinical oncology

authors： Tani M,Tanimura H,Terasawa H,Yamade N,Shono Y,Yamaue H

更新日期：1999-12-01 00:00:00

abstract：:A 77-year-old man presented with painful swelling of his Port-A-Cath insertion site soon after flushing with normal saline. No discomfort or abnormality was found during the saline flush. A chest roentgenogram showed that the disconnected catheter had separated from the disc and was absent from its original location. ...

journal_title：Japanese journal of clinical oncology

authors： Lam AW,Chen YM,Yang KY,Tsai CM,Perng RP

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:The aims of this randomized, controlled study were to investigate the efficacy and safety of long-term monotherapy with the luteinizing hormone-releasing hormone agonist goserelin acetate compared with both short- and long-term combined androgen blockade. METHODS:Patients with advanced prostate cancer (n = 3...

journal_title：Japanese journal of clinical oncology

authors： Kotake T,Usami M,Akaza H,Koiso K,Homma Y,Kawabe K,Aso Y,Orikasa S,Shimazaki J,Isaka S,Yoshida O,Hirao Y,Okajima E,Naito S,Kumazawa J,Kanetake H,Saito Y,Ohi Y,Ohashi Y

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:To estimate the effect of tumor volume on local-regional control of pharyngolaryngeal cancer by radiotherapy (RT). METHODS:Definitive RT for 48 patients with squamous cell carcinoma of the lateral wall of the oropharynx, pyriform sinus and supraglottic larynx was reviewed. Tumor volume was estimated from co...

journal_title：Japanese journal of clinical oncology

authors： Kawashima M,Ogino T,Fujii H,Ishikura S,Ito Y,Ikeda H

更新日期：1999-10-01 00:00:00

abstract：:A 21-year-old man had undergone central bisegmentectomy of the liver due to fibrolamellar carcinoma (FLC). Twice, 24 and 30 months after the first operation, lymph node metastases were removed. We have reported this case previously and this is the second report of the same case. Forty-two months after the second opera...

journal_title：Japanese journal of clinical oncology

authors： Yamamoto H,Watanabe K,Nagata M,Yano Y,Akai T,Honda I,Watanabe S,Soda H,Matsuzaki O

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone. METHODS:A...

journal_title：Japanese journal of clinical oncology

authors： Kobayashi Y,Nakayama M,Uemura N,Takeyama K,Tobinai K,Takenaka T,Choi SH,Satoh H,Mori S,Asano S

更新日期：1999-08-01 00:00:00

abstract：:The occurrence of multiple primary cancers in the aerodigestive tract is a well known phenomenon that has been explained by the concept of 'field carcinogenesis'. Metachronous or synchronous esophageal cancer has usually been identified in patients with head and neck cancer, gastric cancer or colon cancer. The inciden...

journal_title：Japanese journal of clinical oncology

authors： Naomoto Y,Haisa M,Yamatsuji T,Shirakawa Y,Muramatsu T,Isozaki H,Kamikawa Y,Tanaka N

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The detection of prostate-specific antigen (PSA) molecular forms such as free PSA and PSA-ACT and the use of PSA molecular ratios, especially the percentage of free to total PSA, have been reported to improve the diagnostic accuracy of prostate cancer in the patients with slightly elevated serum PSA values. ...

journal_title：Japanese journal of clinical oncology

authors： Kuriyama M,Uno H,Ueno K,Hamamoto Y,Vihn PQ,Ban Y

更新日期：1999-06-01 00:00:00

abstract：:Cases of hyperfractionated radiotherapy and adjuvant chemotherapy for nasopharyngeal cancer are reported. Seven patients received hyperfractionated radiotherapy (76.8-81.6 Gy/64-68 fractions to primary tumor) and two cycles of cisplatin (80 mg/m2 i.v. on day 1) plus 5-FU (800 mg/m2 continuous infusion on days 2-6). Mu...

journal_title：Japanese journal of clinical oncology

authors： Toita T,Ogawa K,Kamata M,Kojya S,Itokazu T,Kakinohana Y,Iraha S,Yoshinaga M,Zukeran Y,Sawada S

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:We aimed to assess the potency and efficacy of tropisetron, a 5-HT3 receptor antagonist, in the prevention of nausea and emesis observed in the pediatric patient population taking various chemotherapy protocols. METHODS:Tropisetron (Navoban) was given to 100 children (62 boys and 38 girls aged 6 months to 1...

journal_title：Japanese journal of clinical oncology

authors： Ozkan A,Yildiz I,Yüksel L,Apak H,Celkan T

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:A self-administered quantitative food frequency questionnaire (Qx) was developed for a population-based cohort study on cancer in Takayama, Japan. METHODS:The Qx was tested among 58 male and 59 female volunteers. Average daily nutrient intakes for the previous year calculated from the Qx were compared with ...

journal_title：Japanese journal of clinical oncology

authors： Shimizu H,Ohwaki A,Kurisu Y,Takatsuka N,Ido M,Kawakami N,Nagata C,Inaba S

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:It is common that patients with head and neck cancers have secondary malignant neoplasm of esophageal cancer. METHODS:To know the genetic background of the development of these secondary cancers, we performed microsatellite assay at six loci and immunohistochemical analysis on head and neck cancers of eight...

journal_title：Japanese journal of clinical oncology

authors： Kiriu H,Yokozaki H,Yasui W,Ito K,Tahara E

更新日期：1998-12-01 00:00:00